- Transition metal-catalyzed synthesis and reactivity of N-alkenyl aziridines.
Transition metal-catalyzed synthesis and reactivity of N-alkenyl aziridines.
Organic letters (2005-03-12)
Shadi Dalili, Andrei K Yudin
PMID15760164
초록
[reaction: see text] Straightforward methods for palladium-catalyzed alkenylation of aziridines with alkenyl halides and copper-catalyzed alkenylation of aziridines with alkenyl boronic acids have been developed. This methodology offers attractive alternatives to the known methods requiring activated alkenyl halides and acetylenes. A wide variety of N-alkenyl aziridines containing substituents other than electron-withdrawing substituents such as cyano groups and sulfones have been synthesized in good yields. Furthermore, these N-alkenyl aziridines exhibit quite a different reactivity from conventional enamines, as demonstrated by their reactivity.
MATERIALS