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Merck

Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.

International journal of biological sciences (2023-11-06)
Mengting Chen, Qinqin Peng, Zixin Tan, San Xu, Yunying Wang, Aike Wu, Wenqin Xiao, Qian Wang, Hongfu Xie, Ji Li, Wei Shi, Zhili Deng
초록

Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4+ T cells of both rosacea patients and experimental mice. Specifically, AQP3 deletion blocked the development of rosacea-like skin inflammation in model mice with LL37-induced rosacea-like disease. We also present mechanistic evidence showing that AQP3 was essential to the activation of NF-κB signaling and subsequent production of disease-characteristic chemokines in keratinocytes. Moreover, we show that AQP3 was upregulated during T cell differentiation and promotes helper T (Th) 17 differentiation possibly via the activation of STAT3 signaling. Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.

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Sigma-Aldrich
Anti-CD28 Mouse mAb (ANC28.1/5D10), liquid, >95% (immunoglobulin, SDS-PAGE), clone ANC28.1/5D10