Anodic electrochemical oxidation of cholic acid.

Anodic electrochemical oxidation of cholic acid.

Steroids (2001-01-09)

A Medici, P Pedrini, A De Battisti, G Fantin, M Fogagnolo, A Guerrini

초록

Regioselectivity in the anodic electrochemical oxidation of cholic acid with different anodes is described. The oxidation with PbO(2) anode affords the dehydrocholic acid in quantitative yield after 22 h. 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholan-24-oic acid (59%) and 3alpha-hydroxy-7,12-dioxo-5beta-cholan-24-oic acid (51%) are obtained stopping the reaction at lower time. The rate of the OH-oxidation is C7 > C12 > C3. The electro-oxidation with platinum foil anode gives selectively the 7-ketocholic acid in 40% yield. On the other hand, the graphite plate anode, varying the reaction conditions, produces selectively the dehydrocholic acid in quantitative yield or the 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid (96%) while the 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid (34%) is obtained together with the other oxo acids.

MATERIALS

제품 번호

브랜드

제품 설명

GF72782231

Platinum, foil, 50x50mm, thickness 0.1mm, as rolled, 99.99+%

GF83172269

Platinum, foil, 0.05m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF72566657

Platinum, foil, 0.1m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF96238570

Platinum, foil, not light tested, 50x50mm, thickness 0.01mm, as rolled, 99.95%

GF87686173

Platinum, foil, 30x30mm, thickness 0.2mm, as rolled, 99.95%

GF92036235

Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.99+%

GF69099610

Platinum, foil, light tested, 50x50mm, thickness 0.05mm, as rolled, 99.95%

GF68611237

Platinum, foil, 0.2m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF83202083

Platinum, foil, 0.2m coil, thickness 0.045mm, coil width .75mm, as rolled, 99.95%

GF98759200

Platinum, foil, not light tested, 100x100mm, thickness 0.0125mm, as rolled, 99.95%

GF95421450

Platinum, foil, not light tested, 100x100mm, thickness 0.01mm, as rolled, 99.95%

GF80931955

Platinum, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99.95%

GF81015465

Platinum, foil, light tested, 50x50mm, thickness 0.025mm, as rolled, 99.99+%

GF77270407

Platinum, foil, not light tested, 50x50mm, thickness 0.003mm, as rolled, 99.95%

GF72819715

Platinum, foil, 25x25mm, thickness 0.25mm, as rolled, 99.99+%

GF90827185

Platinum, foil, not light tested, 50x50mm, thickness 0.0125mm, as rolled, 99.95%

GF02102948

Platinum, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%

GF45750944

Platinum, foil, not light tested, 25x25mm, thickness 0.0075mm, as rolled, 99.95%

GF02450180

Platinum, foil, not light tested, 50x50mm, thickness 0.00075mm, permanent polyester support, 99.85%

GF33460084

Platinum, foil, not light tested, 50x50mm, thickness 0.0025mm, as rolled, 99.95%

GF09598809

Platinum, foil, 0.5m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF07973961

Platinum, foil, 0.5m coil, thickness 0.025mm, coil width .85mm, as rolled, 99.95%

GF15087203

Platinum, foil, 0.1m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%

GF30259357

Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.95%

GF04529538

Platinum, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%

GF55534046

Platinum, foil, 0.05m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF61053476

Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 5mm, as rolled, 99.95%

GF13420257

Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 5mm, as rolled, 99.95%

GF05432936

Platinum, foil, 0.05m coil, thickness 0.030mm, coil width .7mm, as rolled, 99.95%

GF58265488

Platinum, foil, not light tested, 50x50mm, thickness 0.004mm, as rolled, 99.95%