Synthesis of the key precursor of Hirsutellide A.

Synthesis of the key precursor of Hirsutellide A.

Molecules (Basel, Switzerland) (2007-11-17)

Yanjie Xu, Xuemin Duan, Meiling Li, Liqin Jiang, Guangle Zhao, Yi Meng, Ligong Chen

초록

Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.

MATERIALS

제품 번호

브랜드

제품 설명

15140

Sigma-Aldrich

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride, ≥97.0% (AT)