Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

초록

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS

제품 번호

브랜드

제품 설명

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

357375

Sigma-Aldrich

Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

GF68611237

Platinum, foil, 0.2m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF72782231

Platinum, foil, 50x50mm, thickness 0.1mm, as rolled, 99.99+%

771937

Sigma-Aldrich

Platinum, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

GF83202083

Platinum, foil, 0.2m coil, thickness 0.045mm, coil width .75mm, as rolled, 99.95%

GF76686924

Platinum, wire reel, 10m, diameter 0.08mm, hard, 99.9%

GF83172269

Platinum, foil, 0.05m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF98759200

Platinum, foil, not light tested, 100x100mm, thickness 0.0125mm, as rolled, 99.95%

GF78532319

Platinum, wire reel, 0.05m, diameter 0.175mm, as drawn, 99.95%

GF93413493

Platinum, wire reel, 0.1m, diameter 0.15mm, annealed, may be used as one component of a thermocouple, 99.99%

GF74454824

Platinum, wire reel, 0.1m, diameter 0.006mm, wollaston, 99.9%

GF72566657

Platinum, foil, 0.1m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF87506208

Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%

GF80931955

Platinum, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99.95%

GF90209684

Platinum, wire reel, 0.5m, diameter 0.0006mm, wollaston, 99.9%

GF76687105

Platinum, wire reel, 0.5m, diameter 0.15mm, annealed, may be used as one component of a thermocouple, 99.99%

GF76210994

Platinum, wire reel, 1m, diameter 0.0006mm, wollaston, 99.9%

GF88759579

Platinum, wire reel, 10m, diameter 0.04mm, annealed, may be used as one component of a thermocouple, 99.99%