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BioSPME: A Novel Sample Preparation of Clinically Relevant Analytes


Measurements of free hormone levels are routinely performed in clinical applications to help diagnose health concerns. There are two primary methods that have been used for quantification: immunoassays and liquid chromatography tandem mass spectrometry (LC-MS/MS) usually in conjunction with a sample preparatory technique like equilibrium dialysis (ED); with ED considered the “gold-standard.”

A new technology, BioSPME (Bioanalytical Solid Phase MicroExtraction), has been developed to provide a high throughput automatable cleaner sample in a fraction of time compared to ED.

In this webinar, we will discuss:

  • What is BioSPME
  • How does BioSPME work
  • Several applications of clinically relevant free hormones correlated against validated equilibrium dialysis samples


M. James Ross

M. James Ross


Senior Scientist

M. James Ross is a senior scientist at MilliporeSigma. In his past 2.5 years with the company, he has focused on sample preparation primarily dealing with biological samples. James received his BA in Chemistry from Hiram College and his Ph.D. from The Ohio State University.

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