HomeWebinarsBuilding Better Degraders: Targeted Protein Degradation Partners from Lead Discovery to Production

Building Better Degraders: Targeted Protein Degradation Partners from Lead Discovery to Production


Targeted Protein Degradation (TPD) has created a paradigm shift and emerged as a front-runner in drugging many "undruggable" targets. As a new modality, it poses unique challenges for lead discovery as well as API development and manufacturing.

We will focus on the latest advances in chemical building blocks for protein degradation, including warheads, linkers, and ligands, and how they can be used to build better degraders. Once a candidate has been identified, selection of the right CDMO can take a phase-appropriate approach to develop with commercial readiness in mind, provide partnered quality and regulatory support, and offer batch scalability as you progress through the clinic.

In this webinar, you will learn about:

  • Targeted Protein Degradation (TPD) technologies
  • A mechanistic view of this new modality
  • Chemical advancements for modular and strategic degrader design 
  • How to select the appropriate contract manufacturing partner


Aditya S. Vaidya

Aditya S. Vaidya

Chemical Biology Innovation

Senior Scientist

Aditya Vaidya is a senior scientist in the Chemical Biology Innovation Team at SLS Chemistry. His work focuses on creating innovative solutions for the chemical biology and drug discovery community, including novel tools for targeted protein degradation, which is considered the next gold rush in drug discovery. He is dedicated to providing cutting-edge products that can revolutionize drug discovery and lead to improvements in human health. Aditya holds a Ph.D. in medicinal chemistry from the University of Illinois at Chicago and has over 10 years of experience in the field of drug discovery. 

Hugo Matos Viana

Hugo Matos Viana


Global Product Manager - Chemical Biology

Hugo Matos Viana is a Portuguese life science professional based in the UK since 2016. Hugo is a seasoned professional with extensive technical and business expertise, particularly in the fields of marketing, sales, and product-based projects. In his current role, he is responsible for overseeing the strategy of MilliporeSigma's global chemical biology portfolio. Hugo holds a Ph.D. in organic chemistry from the Universities of Évora (Portugal)/Max Planck Institute for Colloids and Interfaces (Germany).

Jason Modest

Jason Modest


Director of Manufacturing, Science and Technology

Jason Modest has been in the pharmaceutical industry for 25 years and is the director of the manufacturing, science, and technology department at the Madison/Verona, WI site. He leads the technical transfer and validation teams and provides life cycle management for commercial programs. Transitioning into technical operations positions in brand, generic, and the CDMO space has allowed for a comprehensive understanding of what is required to successfully move early-phase development programs to commercial launch. Jason holds a bachelor’s degree in biochemistry from Fort Lewis College.

Jacqueline Ruff

Jacqueline Ruff


Strategic Marketing Manager

Jacqueline Ruff is a strategic marketing manager leading marketing initiatives for the growing small molecule CTDMO landscape at MilliporeSigma. Prior to joining the marketing franchise, she gained experience in small molecule CDMO operations through her roles in project management and quality management. Jackie received bachelor's degrees in both genetics and life science communication at the University of Wisconsin, and her Master's in biotechnology enterprise and entrepreneurship from Johns Hopkins University.

Webinar Information

Pharma and biopharma manufacturing

  • Detecting & Removing Aggregates
  • Duration:1h

  • Language:English

  • Session 1:presented June 15, 2023

    Register Now

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