MilliporeSigma

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Synonyms:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Species:
UniProtKB ID:
Gene ID:
  • Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
  • dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Thale Cress(818265) ABC transporter B family member 1
  • naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1

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Small Molecule - Agonist

Product Number
Description
Species
9(10H)-Acridanone, 99%,
Species
human
Hydrocortisone-Water Soluble, BioReagent, suitable for cell culture,
Species
human, mouse, rat
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture,
Species
human, mouse, rat
Hydrocortisone, BioReagent, suitable for cell culture,
Species
human, mouse, rat
Hydrocortisone, ≥98% (HPLC),
Species
human, mouse, rat

Small Molecule - Antagonist

Product Number
Description
Species
Chlorosulfonyl isocyanate, 98%,
Species
human
Ivermectin, ,
Species
mouse, human
Omeprazole, solid,
Species
human
Erythromycin, meets USP testing specifications,
Species
mouse, human
Clotrimazole, ,
Species
mouse, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ABCB1 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse, clone F4, ascites fluid,
Species Reactivity
hamster, human
Application
ELISA
immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

radioimmunoassay

western blot
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-P Glycoprotein Antibody, clone 2U4E9, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
Anti-MDR-1 Antibody, clone 1O12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse
Application
affinity binding assay
flow cytometry

immunocytochemistry

immunohistochemistry

western blot

Cell Lines

Product Number
Description
Species
CAR Knockout HepaRG Cells, 1 vial,
Species
MDR1 Knockout Caco-2 Cells, one vial,
Species
human
SB-cyMDR1-HEK293, ,
Species
SB-MDR1-HEK293, recombinant, expressed in HEK 293 cells,
Species
human
Kidney PTEC MDR1 KnockoutCells [MDR1 knock out (-/-)], ,
Species
human

Kits

Product Number
Description
Species
Multidrug Resistance Assay Kit, (Fluorometric MDR Assay),
Species
human, mouse, rat

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Dexamethasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Species
mouse, rat, human
Dexamethasone, powder, BioReagent, suitable for cell culture, ≥97%,
Species
mouse, rat, human
Dexamethasone, ≥98% (HPLC), powder,
Species
mouse, rat, human
Dexamethasone, meets USP testing specifications,
Species
mouse, rat, human
Dexamethasone, tested according to Ph. Eur.,
Species
mouse, rat, human

Proteins

Product Number
Description
Species
SB-MDR1-Hi5-PREDEASY-ATPase kit, membrane based kit for Human MDR1 ATPase Transport Assays,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ABCB1,
Species
human