MilliporeSigma

ACLY

ATP citrate lyase

Synonyms:
ACL, ATPCL, CLATP
Species:
UniProtKB ID:
Gene ID:
  • Human(47) Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(104112) ATP citrate lyase
  • Rat(24159) ATP citrate lyase
  • chicken(395373) ATP citrate lyase
  • naked mole-rat(101700349) ATP citrate lyase
  • domestic guinea pig(100714933) ATP citrate lyase
  • dog(607852) ATP citrate lyase
  • Horse(100053195) ATP citrate lyase
  • domestic cat(100422779) ATP citrate lyase
  • cow(511135) ATP citrate lyase
  • sheep(654404) ATP citrate lyase

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ACLY antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-ACLY antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-ACLY antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-ACLY antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-phospho-ATP-Citrate Lyase (pSer454) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Proteins

Product Number
Description
Species
ATP Citrate Lyase Active human, recombinant, expressed in baculovirus, ≥90% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Acly,
Species
mouse
MISSION® esiRNA, targeting human ACLY,
Species
human