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ALDH2

aldehyde dehydrogenase 2 family (mitochondrial)

Synonyms:
ALDH-E2, ALDHI, ALDM
Species:
UniProtKB ID:
Gene ID:
  • Human(217) Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]
  • Mouse(11669) aldehyde dehydrogenase 2, mitochondrial
  • Rat(29539) aldehyde dehydrogenase 2 family (mitochondrial)
  • naked mole-rat(101706449) aldehyde dehydrogenase 2 family (mitochondrial)
  • sheep(101116511) aldehyde dehydrogenase 2 family (mitochondrial)
  • domestic guinea pig(100730314) aldehyde dehydrogenase 2 family (mitochondrial)
  • dog(610941) aldehyde dehydrogenase 2 family (mitochondrial)
  • domestic cat(101082267) aldehyde dehydrogenase 2 family (mitochondrial)
  • cow(508629) aldehyde dehydrogenase 2 family (mitochondrial)
  • Domestic Rabbit(100338523) aldehyde dehydrogenase 2 family (mitochondrial)
  • chicken(416880) aldehyde dehydrogenase 2 family (mitochondrial)

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ALDH2 antibody produced in mouse, clone 4F10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Monoclonal Anti-ALDH2 antibody produced in mouse, clone 4C11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-ALDH2 Mouse mAb (1E5), liquid, clone 1E5, Calbiochem®,
Species Reactivity
human
Application
Monoclonal Anti-ALDH2 antibody produced in mouse, clone 1E5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-ALDH2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Disulfiram, European Pharmacopoeia (EP) Reference Standard,
Species
human
Disulfiram, United States Pharmacopeia (USP) Reference Standard,
Species
human
Disulfiram, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Disulfiram, British Pharmacopoeia (BP) Reference Standard,
Species
human
Tetraethylthiuram disulfide, ≥97.0% (S),
Species
human

Proteins

Product Number
Description
Species
ALDH2 human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ALDH2,
Species
human
MISSION® esiRNA, targeting mouse Aldh2,
Species
mouse