MilliporeSigma

APP

amyloid beta (A4) precursor protein

Synonyms:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Species:
UniProtKB ID:
Gene ID:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
Human APP / Amyloid Beta A4 Protein ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human
Human Amyloid β42 Brain ELISA, This Human Amyloid β42 Brain ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.,
Species
human
Human Amyloid β40 and Amyloid β42 Brain ELISA, ,
Species
human
High Sensitivity Human Amyloid β42 ELISA, This High Sensitivity Human Amyloid β42 ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.,
Species
human
High Sensitivity Human Amyloid β40 and Amyloid β42 ELISA, ,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
BTA-1, ≥98% (HPLC), solid,
Species
human
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin),
Species
human
Curcumin, from Curcuma longa (Turmeric), powder,
Species
human
Flurbiprofen, cyclooxygenase inhibitor,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-APP (ab2) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-APP (ab3) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
Anti-App (N-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
mouse, rat
Application
ELISA
western blot
Anti-β-Amyloid antibody, Mouse monoclonal, clone NAB 228, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

microarray

western blot
Anti-APP (Ab-668) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot

Proteins

Product Number
Description
Species
Amyloid β-Protein Fragment 17-40, ≥87% (HPLC), lyophilized powder,
Species
human
Amyloid Precursor Protein β, Secreted human, recombinant, expressed in E. coli (N-terminal histidine tagged), solution,
Species
human
β Amyloid 1-42, aβ, scrambled, TFA, recombinant E. coli, ,
Species
human
β Amyloid 1-42, aβ, ultra pure, NaOH, recombinant human, ,
Species
human
Acetyl-Amyloid β-Protein Fragment 15-20 Amide, ≥97% (HPLC), powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse App,
Species
mouse
MISSION® esiRNA, targeting human APP,
Species
human