MilliporeSigma

AVPR2

arginine vasopressin receptor 2

Synonyms:
ADHR, DI1, DIR, DIR3, NDI, V2R
Species:
UniProtKB ID:
Gene ID:
  • Human(554) Summary: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
  • Mouse(12000) arginine vasopressin receptor 2
  • Rat(25108) arginine vasopressin receptor 2
  • chicken(427860) arginine vasopressin receptor 2
  • sheep(100528011) arginine vasopressin receptor 2
  • cow(281642) arginine vasopressin receptor 2
  • Domestic Rabbit(100328747) arginine vasopressin receptor 2
  • domestic guinea pig(100712605) arginine vasopressin receptor 2
  • naked mole-rat(101725573) arginine vasopressin receptor 2
  • dog(403804) arginine vasopressin receptor 2
  • domestic cat(101082135) arginine vasopressin receptor 2

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Small Molecule - Agonist

Product Number
Description
Species
[deamino-Cys1, Val4, D-Arg8]-Vasopressin, ≥95%,
Species
mouse, rat, human
[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate, ≥95% (HPLC),
Species
mouse, rat, human
[Arg8]-Vasopressin acetate salt, ≥95% (HPLC),
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Tolvaptan, ≥98% (HPLC), powder,
Species
human
[β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-Et-Tyr2, Val4, Arg8]-Vasopressin, ≥97% (HPLC),
Species
mouse, rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-AVPR2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
hamster, human, monkey, mouse, rabbit, rat
Application
immunohistochemistry
Anti-AVPR2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-AVPR2 (C-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-Arginine Vasopressin Receptor V2 Antibody, Chemicon®, from rabbit,
Species Reactivity
rat
Application
ELISA
immunohistochemistry

western blot
Anti-Vasopressin V2 Receptor Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry