MilliporeSigma

BCL2L11

BCL2-like 11 (apoptosis facilitator)

Synonyms:
BAM, BIM, BOD
Species:
UniProtKB ID:
Gene ID:
  • Human(10018) Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
  • Mouse(12125) BCL2-like 11 (apoptosis facilitator)
  • Rat(64547) BCL2-like 11 (apoptosis facilitator)
  • naked mole-rat(101721800) BCL2-like 11 (apoptosis facilitator)
  • domestic guinea pig(100725284) BCL2-like 11 (apoptosis facilitator)
  • domestic cat(101084615) BCL2-like 11 (apoptosis facilitator)
  • cow(507390) BCL2-like 11 (apoptosis facilitator)
  • domestic cat(768267) BCL2-like 11 (apoptosis facilitator)
  • Zebrafish(100190951) BCL2-like 11
  • sheep(100505402) BCL2-like 11 (apoptosis facilitator)
  • dog(612867) BCL2-like 11 (apoptosis facilitator)

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-BCL2L11 antibody produced in mouse, clone 2F10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-BimEL (pS69) human / (pS65) rat Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-BIM antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-BIM antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
ANTI-BIM BH3 DOMAIN antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human BCL2L11,
Species
human
MISSION® esiRNA, targeting mouse Bcl2l11,
Species
mouse