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C5

complement component 5

Synonyms:
C5a, C5b, CPAMD4
Species:
UniProtKB ID:
Gene ID:
  • Human(727) Summary: The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]
  • Rat(362119) complement component 5
  • chicken(417122) complement component 5
  • Zebrafish(565774) complement component 5
  • cow(512045) complement component 5
  • domestic cat(101090401) complement component 5
  • dog(474816) complement component 5
  • naked mole-rat(101710435) complement component 5
  • domestic guinea pig(100733000) complement component 5
  • sheep(101121825) complement component 5

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ELISA

Product Number
Description
Species
Mouse C5a / Complement C5a ELISA Kit, for serum, plasma and cell culture supernatants,
Species
mouse
Human C5a / Complement C5a ELISA Kit, for serum, plasma, and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Complement C5 Antibody, clone SIM 225-3.2.1, ,
Species Reactivity
canine, feline, goat, guinea pig, human, porcine, rabbit, rat
Application
ELISA
flow cytometry

western blot
Anti-C5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Proteins

Product Number
Description
Species
Complement C5 from human serum, ≥90% (SDS-PAGE), >100,000 C5H50 units/mg protein,
Species
human
Complement C5 deficient serum human, for complement assays,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human C5,
Species
human