CASP1
caspase 1, apoptosis-related cysteine peptidase
Synonyms:
ICE, IL1BC, P45
Species:
Human CASP1 (834), Mouse Casp1 (12362), Rat Casp1 (25166), chicken CASP1 (395764), cow CASP1 (514214), Horse CASP1 (100033888), domestic cat CASP1 (493961), naked mole-rat Casp1 (101725179)
UniProtKB ID:
Gene ID:
- Human(834) Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
- Mouse(12362) caspase 1
- Rat(25166) caspase 1
- chicken(395764) caspase 1, apoptosis-related cysteine peptidase
- cow(514214) caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
- Horse(100033888) caspase 1, apoptosis-related cysteine peptidase
- domestic cat(493961) caspase 1, apoptosis-related cysteine peptidase
- naked mole-rat(101725179) caspase 1, apoptosis-related cysteine peptidase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Caspase-1 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-CASP1 antibody produced in mouse, clone 3D2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CASP1, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Caspase-1 (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Small Molecule - Inhibitor
esiRNA
Product Number
Description
Species