MilliporeSigma

CDC25B

cell division cycle 25B

Synonyms:
Species:
UniProtKB ID:
Gene ID:
  • Human(994) Summary: CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
  • Mouse(12531) cell division cycle 25B
  • Rat(171103) cell division cycle 25B
  • domestic guinea pig(100716851) cell division cycle 25B
  • naked mole-rat(101701077) cell division cycle 25B
  • cow(505847) cell division cycle 25 homolog B (S. pombe)
  • dog(485790) cell division cycle 25 homolog B (S. pombe)
  • Horse(100052425) cell division cycle 25 homolog B (S. pombe)
  • domestic cat(101092757) cell division cycle 25 homolog B (S. pombe)
  • sheep(101120511) cell division cycle 25 homolog B (S. pombe)

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-CDC25B (pSer353) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-phospho-Cdc25b (pSer149) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
mouse
Application
western blot
Monoclonal Anti-CDC25B antibody produced in mouse, clone 7E8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-CDC25B (AB2) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
guinea pig, human
Application
immunohistochemistry
western blot
Anti-phospho-CDC25B (pSer353) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
western blot

Cell Lines

Product Number
Description
Species
MCF10A CELLS CDC25B (-/-), ,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
NSC 95397, ≥97% (HPLC),
Species
human
NSC 663284, ≥98% (HPLC), solid,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CDC25B,
Species
human
MISSION® esiRNA, targeting mouse Cdc25b,
Species
mouse