MilliporeSigma

CYP1A1

cytochrome P450, family 1, subfamily A, polypeptide 1

Synonyms:
AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
Species:
UniProtKB ID:
Gene ID:
  • Human(1543) Summary: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]
  • Mouse(13076) cytochrome P450, family 1, subfamily a, polypeptide 1
  • Rat(24296) cytochrome P450, family 1, subfamily a, polypeptide 1
  • sheep(100170113) cytochrome P4501A1
  • Horse(100062285) cytochrome P450, family 1, subfamily A, polypeptide 1
  • domestic cat(554347) cytochrome P450 1A1
  • cow(282870) cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
  • dog(100686778) cytochrome P450, family 1, subfamily A, polypeptide 1
  • dog(487648) cytochrome P450
  • domestic guinea pig(100135512) cytochrome P450, family 1, subfamily a, polypeptide 1
  • chicken(396051) cytochrome P450, family 1, subfamily A, polypeptide 1

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CYP1A1 (AB3), affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Monoclonal Anti-CYP1A1 antibody produced in mouse, clone 6G5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot
Anti-CYP1A1 (AB2), affinity isolated antibody,
Species Reactivity
bovine, guinea pig, horse, human, mouse, rabbit, rat, sheep
Application
immunohistochemistry
western blot

Cell Lines

Product Number
Description
Species
CypExpress 1A1 Cytochrome P450 human, ,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Rutaecarpine, >98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
Cytochrome P450 human, 1A1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CYP1A1,
Species
human