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DUSP10

dual specificity phosphatase 10

Synonyms:
MKP-5, MKP5
Species:
UniProtKB ID:
Gene ID:
  • Human(11221) Summary: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(63953) dual specificity phosphatase 10
  • Rat(63995) dual specificity phosphatase 10
  • Domestic Rabbit(100352279) dual specificity phosphatase 10
  • naked mole-rat(101715205) dual specificity phosphatase 10
  • domestic cat(101096697) dual specificity phosphatase 10
  • Horse(100050108) dual specificity phosphatase 10
  • domestic guinea pig(100733434) dual specificity phosphatase 10
  • sheep(101106025) dual specificity phosphatase 10
  • dog(488673) dual specificity phosphatase 10
  • chicken(421340) dual specificity phosphatase 10
  • cow(541175) dual specificity phosphatase 10

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-DUSP10/MKP5 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, mouse, rat
Application
ELISA
western blot
Anti-DUSP10 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Dusp10,
Species
mouse
MISSION® esiRNA, targeting human DUSP10,
Species
human