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DUSP5

dual specificity phosphatase 5

Synonyms:
DUSP, HVH3
Species:
UniProtKB ID:
Gene ID:
  • Human(1847) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
  • Mouse(240672) dual specificity phosphatase 5
  • Rat(171109) dual specificity phosphatase 5
  • naked mole-rat(101726329) dual specificity phosphatase 5
  • domestic guinea pig(100729004) dual specificity phosphatase 5
  • cow(507061) dual specificity phosphatase 5
  • domestic cat(101098828) dual specificity phosphatase 5
  • Domestic Rabbit(100343162) dual specificity phosphatase 5
  • sheep(101118748) dual specificity phosphatase 5
  • chicken(423890) dual specificity phosphatase 5
  • Zebrafish(114436) dual specificity phosphatase 5
  • dog(486884) dual specificity phosphatase 5

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-DUSP5 antibody produced in mouse, clone 2F3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, rat
Application
ELISA
immunofluorescence

western blot
Monoclonal Anti-DUSP5 antibody produced in mouse, clone 2F3, ascites fluid, solution,
Species Reactivity
human, rat
Application
ELISA
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human DUSP5,
Species
human
MISSION® esiRNA, targeting mouse Dusp5,
Species
mouse