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KCNJ11

potassium inwardly-rectifying channel, subfamily J, member 11

Synonyms:
BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3
Species:
UniProtKB ID:
Gene ID:
  • Human(3767) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(16514) potassium inwardly rectifying channel, subfamily J, member 11
  • Rat(83535) potassium inwardly rectifying channel, subfamily J, member 11
  • domestic cat(101097019) potassium inwardly-rectifying channel, subfamily J, member 11
  • sheep(101114135) potassium inwardly-rectifying channel, subfamily J, member 11
  • Horse(100056520) potassium inwardly-rectifying channel, subfamily J, member 11
  • Zebrafish(664687) potassium inwardly-rectifying channel, subfamily J, member 11
  • Domestic Rabbit(100008648) potassium inwardly-rectifying channel, subfamily J, member 11
  • naked mole-rat(101705172) potassium inwardly-rectifying channel, subfamily J, member 11
  • dog(485401) potassium inwardly-rectifying channel, subfamily J, member 11
  • chicken(428846) potassium inwardly-rectifying channel, subfamily J, member 11
  • cow(532060) potassium inwardly-rectifying channel, subfamily J, member 11
  • domestic guinea pig(100135564) potassium inwardly rectifying channel, subfamily J, member 11

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Small Molecule - Antagonist

Product Number
Description
Species
Glyburide, meets USP testing specifications,
Species
rat, human
Glybenclamide, ≥99% (HPLC),
Species
rat, human
Chlorpropamide, analytical standard, ≥97%,
Species
human, mouse
Tolbutamide, analytical standard,
Species
human, mouse
Diazoxide, ,
Species
rat, mouse, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-KCNJ11 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-KIR6.2 (PHOSPHO-THR224), affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
Anti-KIR6.2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-Potassium Channel Kir6.2 Antibody, Chemicon®, from rabbit,
Species Reactivity
rat
Application
western blot
Anti-KCNJ11/KATP antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Blocker

Product Number
Description
Species
Glipizide, European Pharmacopoeia (EP) Reference Standard,
Species
human
Glyburide (Glibenclamide), Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Glimepiride for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Glimepiride for system suitability, British Pharmacopoeia (BP) Reference Standard,
Species
human
Glimepiride, British Pharmacopoeia (BP) Reference Standard,
Species
human

Small Molecule - Opener

Product Number
Description
Species
Diazoxide, European Pharmacopoeia (EP) Reference Standard,
Species
human
Diazoxide, United States Pharmacopeia (USP) Reference Standard,
Species
human
Diazoxide, ,
Species
rat, mouse, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KCNJ11,
Species
human