KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3
Human KCNJ11 (3767), Mouse Kcnj11 (16514), Rat Kcnj11 (83535), domestic cat KCNJ11 (101097019), sheep KCNJ11 (101114135), Horse KCNJ11 (100056520), Zebrafish kcnj11 (664687), Domestic Rabbit KCNJ11 (100008648), naked mole-rat Kcnj11 (101705172), dog KCNJ11 (485401) ...More
- Human(3767) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
- Mouse(16514) potassium inwardly rectifying channel, subfamily J, member 11
- Rat(83535) potassium inwardly rectifying channel, subfamily J, member 11
- domestic cat(101097019) potassium inwardly-rectifying channel, subfamily J, member 11
- sheep(101114135) potassium inwardly-rectifying channel, subfamily J, member 11
- Horse(100056520) potassium inwardly-rectifying channel, subfamily J, member 11
- Zebrafish(664687) potassium inwardly-rectifying channel, subfamily J, member 11
- Domestic Rabbit(100008648) potassium inwardly-rectifying channel, subfamily J, member 11
- naked mole-rat(101705172) potassium inwardly-rectifying channel, subfamily J, member 11
- dog(485401) potassium inwardly-rectifying channel, subfamily J, member 11
- chicken(428846) potassium inwardly-rectifying channel, subfamily J, member 11
- cow(532060) potassium inwardly-rectifying channel, subfamily J, member 11
- domestic guinea pig(100135564) potassium inwardly rectifying channel, subfamily J, member 11
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Antagonist
Antibodies
Anti-KCNJ11 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
human
immunohistochemistry
Anti-KIR6.2 (PHOSPHO-THR224), affinity isolated antibody,
human, mouse
immunofluorescence
western blot
western blot
Anti-KIR6.2 antibody produced in rabbit, affinity isolated antibody,
human, mouse
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-KCNJ11/KATP antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
human
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Blocker
Glyburide (Glibenclamide), Pharmaceutical Secondary Standard; Certified Reference Material,
human