MilliporeSigma

LAMB1

laminin, beta 1

Synonyms:
CLM, LIS5
Species:
UniProtKB ID:
Gene ID:
  • Human(3912) Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]
  • Mouse(16777) laminin B1
  • Rat(298941) laminin, beta 1
  • naked mole-rat(101700233) laminin, beta 1
  • cow(520030) laminin, beta 1
  • chicken(396478) laminin, beta 1
  • Horse(100060360) laminin, beta 1
  • domestic guinea pig(100721521) laminin, beta 1
  • dog(475882) laminin, beta 1
  • domestic cat(101080367) laminin, beta 1
  • sheep(101105743) laminin, beta 1
  • Domestic Rabbit(100358679) laminin, beta 1

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-LAMB1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL2970, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-LAMB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-LAMB1 antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-Laminin β1 Antibody, clone 4E10 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry

western blot
Anti-Laminin β1 Antibody, clone 3E5, ,
Species Reactivity
human, rat
Application
ELISA
electron microscopy

western blot

Proteins

Product Number
Description
Species
Laminin from human placenta, liquid, BioReagent, suitable for cell culture,
Species
human
Human Laminin (pepsinized) Purified Protein, ,
Species
human
Laminin from human fibroblasts, cell culture derived, liquid, sterile-filtered,
Species
human
Laminin from Engelbreth-Holm-Swarm murine sarcoma basement membrane, 1-2 mg/mL in Tris-buffered saline, 0.2 μm filtered, BioReagent, suitable for cell culture,
Species
mouse
ECM Gel from Engelbreth-Holm-Swarm murine sarcoma, liquid, BioReagent, suitable for cell culture,
Species
mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human LAMB1,
Species
human
MISSION® esiRNA, targeting mouse Lamb1-1,
Species
mouse