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MilliporeSigma

LMNA

lamin A/C

Synonyms:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Species:
UniProtKB ID:
Gene ID:
  • Human(4000) Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
  • Mouse(16905) lamin A
  • Rat(60374) lamin A/C
  • domestic guinea pig(100735212) lamin A/C
  • chicken(415464) lamin A/C
  • sheep(101107924) lamin A/C
  • cow(404144) lamin A/C
  • domestic cat(101086199) lamin A/C
  • Horse(100057663) lamin A/C
  • dog(480124) lamin A/C
  • Zebrafish(195815) lamin A
  • naked mole-rat(101704567) lamin A/C

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-LMNA antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-Lamin A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-Lamin A−Atto 647N antibody produced in rabbit, 1.5-3 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
Anti-Lamin A (Cleaved-Asp230) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-Lamin A/C Antibody, clone 2E8.2 Antibody, Alexa Fluor 488 Conjugate, clone 2E8.2, from mouse, ALEXA FLUOR 488,
Species Reactivity
human
Application
immunocytochemistry

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human LMNA,
Species
human
MISSION® esiRNA, targeting mouse Lmna,
Species
mouse