MilliporeSigma

MAP3K4

mitogen-activated protein kinase kinase kinase 4

Synonyms:
MAPKKK4, MEKK4, MTK1, PRO0412
Species:
UniProtKB ID:
Gene ID:
  • Human(4216) Summary: The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(26407) mitogen-activated protein kinase kinase kinase 4
  • Rat(308106) mitogen activated protein kinase kinase kinase 4
  • Domestic Rabbit(100358104) mitogen-activated protein kinase kinase kinase 4
  • cow(511779) mitogen-activated protein kinase kinase kinase 4
  • Horse(100058153) mitogen-activated protein kinase kinase kinase 4
  • naked mole-rat(101701961) mitogen-activated protein kinase kinase kinase 4
  • domestic guinea pig(100724828) mitogen-activated protein kinase kinase kinase 4
  • domestic cat(101097977) mitogen-activated protein kinase kinase kinase 4
  • dog(476262) mitogen-activated protein kinase kinase kinase 4
  • Zebrafish(325488) mitogen activated protein kinase kinase kinase 4
  • chicken(421579) mitogen-activated protein kinase kinase kinase 4
  • sheep(101113246) mitogen-activated protein kinase kinase kinase 4

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-MAP3K4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
Monoclonal Anti-MAP3K4 antibody produced in mouse, clone 6C6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
immunohistochemistry

western blot
Anti-MAP3K4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
ANTI-MEKK4 (CENTER C1081) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Monoclonal Anti-MAP3K4 antibody produced in mouse, clone 4C3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Map3k4,
Species
mouse
MISSION® esiRNA, targeting mouse Map3k4,
Species
mouse
MISSION® esiRNA, targeting human MAP3K4,
Species
human