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MAP3K7

mitogen-activated protein kinase kinase kinase 7

Synonyms:
MEKK7, TAK1, TGF1a
Species:
UniProtKB ID:
Gene ID:
  • Human(6885) Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(26409) mitogen-activated protein kinase kinase kinase 7
  • Rat(313121) mitogen activated protein kinase kinase kinase 7
  • Zebrafish(553788) mitogen activated protein kinase kinase kinase 7
  • Horse(100065841) mitogen-activated protein kinase kinase kinase 7
  • Domestic Rabbit(100343571) mitogen-activated protein kinase kinase kinase 7
  • dog(474996) mitogen-activated protein kinase kinase kinase 7
  • chicken(421808) mitogen-activated protein kinase kinase kinase 7
  • domestic guinea pig(100718100) mitogen-activated protein kinase kinase kinase 7
  • naked mole-rat(101718269) mitogen-activated protein kinase kinase kinase 7
  • domestic cat(101095899) mitogen-activated protein kinase kinase kinase 7
  • cow(529146) mitogen-activated protein kinase kinase kinase 7
  • sheep(100294587) mitogen-activated protein kinase kinase kinase 7
  • sheep(101108056) mitogen-activated protein kinase kinase kinase 7

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Phospho-MAP3K7-T187 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
western blot
Anti-TAK1 Antibody, clone 1W2B10, Rabbit Monoclonal, ,
Species Reactivity
mouse
Application
immunoprecipitation (IP)
western blot
Anti-Phospho-TAK1-T187 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
western blot
Anti-phospho-TAK1 (Ser412) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse
Application
western blot
Anti-phospho-TAK1 (pThr184) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot

Proteins

Product Number
Description
Species
TAK1-TAB1 fusion Protein, active, 10 µg, Active, N-terminal His6-tagged, recombinant, human TAK1 amino acids 1-303, fused to human TAB1 amino acids 437-end, for use in Kinase Assays.,
Species
human
TAK1-TAB1 (1-303), (437-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MAP3K7,
Species
human
MISSION® esiRNA, targeting mouse Map3k7,
Species
mouse