MilliporeSigma

MAPK14

mitogen-activated protein kinase 14

Synonyms:
CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
Species:
UniProtKB ID:
Gene ID:
  • Human(1432) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(26416) mitogen-activated protein kinase 14
  • Rat(81649) mitogen activated protein kinase 14
  • naked mole-rat(101715692) mitogen-activated protein kinase 14
  • domestic guinea pig(100723285) mitogen-activated protein kinase 14
  • chicken(421183) mitogen-activated protein kinase 14
  • Horse(100063532) mitogen-activated protein kinase 14
  • dog(403856) mitogen-activated protein kinase 14
  • domestic cat(101101135) mitogen-activated protein kinase 14
  • Domestic Rabbit(100341695) mitogen-activated protein kinase 14
  • sheep(100217411) mitogen-activated protein kinase 14
  • cow(534492) mitogen-activated protein kinase 14

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ELISA

Product Number
Description
Species
Phospho-p38 α (pThr180 / pTyr182) and pan-p38 ELISA Kit, for detection of phospho-p38 alpha (pThr180 / pTyr182) and pan-p38 in human or mouse cell and tissue lysates,
Species
human
Phospho-p38 α (pThr180 / pTyr182) ELISA Kit, fore detection of phospho-p38 alpha (pThr180 / pTyr182) in human or mouse cell and tissue lysates,
Species
human
Phosphotyrosine MAPK14 / Mitogen-activated Protein Kinase 14 ELISA Kit, ,
Species
human
Cell-Based ELISA for detecting phospho-P38 MAPK (pThr180 / pTyr182) in cultured cell lines, 96 assays,
Species
human
Cell-Based ELISA Sampler Kit for detecting phospho-ERK1/2 (pThr202/pTyr204), phospho-JNK (pThr183/pTyr185), and phospho-p38 MAPK (pThr180/pTyr182) in cultured cell lines, 192 assays,
Species
rat, human, mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-MAPK14 (pTyr182) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-phospho-MAPK14 (pThr180) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-MAPK14 (Ab-182) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-phospho-p38 MAPK (pThr179+Tyr181) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-p38 MAPK Antibody, clone 2H9Q5, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
PD 169316, ≥98% (HPLC), solid,
Species
human
TAK-715, ≥98% (HPLC),
Species
human
2-Amino-3-benzyloxypyridine, 99%,
Species
human
SB 202190, ≥98% (HPLC),
Species
human
VX-745, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
p38α/SAPK2a Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.,
Species
human
p38α/SAPK2a (T106M) Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 & repurified using glutathione-agarose. For use in Kinase Assays.,
Species
human
p38α, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MAPK14,
Species
human
MISSION® esiRNA, targeting mouse Mapk14,
Species
mouse