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P9248

Sigma-Aldrich

PD 169316

≥98% (HPLC), solid

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Synonym(s):
4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
Empirical Formula (Hill Notation):
C20H13FN4O2
CAS Number:
Molecular Weight:
360.34
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

color

faint yellow to dark orange

solubility

DMSO: >10 mg/mL
H2O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)

InChI key

BGIYKDUASORTBB-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

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S7067513030559388
PD 169316 ≥98% (HPLC), solid

P9248

PD 169316

SB 202190 ≥98% (HPLC)

S7067

SB 202190

PD 169316 A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

513030

PD 169316

SB 202190 SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (Ki = 16 nM; IC₅₀ = 350 nM).

559388

SB 202190

form

solid

form

powder

form

solid

form

solid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL

solubility

DMSO: 50 mg/mL

originator

GlaxoSmithKline

originator

GlaxoSmithKline

originator

-

originator

-

color

faint yellow to dark orange

color

faintly yellow, to beige

color

orange-yellow

color

pale yellow

General description

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases. It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.

Application

PD 169316 has been used for the inhibition of p38 enzyme in human hepatocytes. It has been used in culture media to promote embryoid bodies differentiation.

Biochem/physiol Actions

Potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

CorrosionSkull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Activation of CD40 with platelet derived CD154 promotes reactive oxygen species dependent death of human hepatocytes during hypoxia and reoxygenation
Bhogal RH, et al.
PLoS ONE, 7(1), e30867-e30867 (2012)
Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons
Nath R, et al.
Cellular & Molecular Biology Letters, 6(2), 173-184 (2001)
A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells
Hadjal Y, et al.
Cell Death & Disease, 4(7), e737-e737 (2013)
The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells
Fu Y, et al.
Biochemical and Biophysical Research Communications, 310(2), 391-397 (2003)
Byoung Kwon Park et al.
Biomolecules & therapeutics, 29(3), 273-281 (2021-01-29)
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Signaling pathways that are essential for virus production have potential as therapeutic targets against COVID-19. In this study, we investigated cellular responses in two

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