S7067

SB 202190

≥98% (HPLC), powder, p38 MAP kinase inhibitor

• Synonym(s): 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
• Empirical Formula (Hill Notation): C₂₀H₁₄FN₃O
• CAS Number: 152121-30-7
• Molecular Weight: 331.34
• MDL number: MFCD00941964
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278272
• NACRES: NA.77

Properties

• product name: SB 202190, ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: faintly yellow, to beige
• solubility: DMSO: 10 mg/mL, clear
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
• InChI: 1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
• InChI key: QHKYPYXTTXKZST-UHFFFAOYSA-N
• Gene Information: human ... MAPK14(1432)

Description

General description

SB202190 aids in enhancing the self-renewal ability of neural stem cells fromNPC1-deficient mice.

Application

SB 202190 has been used:

• to investigate the role of p38mitogen-activated protein kinase (MAPK) signaling in establishment of reovirus infection
• as a p38α inhibitor in in vivo studies to study its impact on the development or progression of adenocarcinoma in the colon mucosa tissues of APC ^Min/+ mice.
• as a component of basic BC medium to culture basal progenitor cells.
• as a component of normal endometrium and endometrial tumor media for organoid culture.

SB 202190 was used to inhibit p38 activation in MCF7 cells⁵, mouse macrophages⁶ and HepG2 cells.⁷

Biochem/physiol Actions

SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase. SB 202190 binds within the ATP pocket of the active kinase (K_d = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves