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72340

Sigma-Aldrich

Nicotinamide

≥99.5% (HPLC)

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Synonym(s):
Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP
Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
Molecular Weight:
122.12
Beilstein/REAXYS Number:
383619
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.79

biological source

synthetic

Quality Level

assay

≥99.5% (HPLC)

form

powder or crystals

ign. residue

≤0.2%

loss

≤0.2% loss on drying, 20 °C (HV)

color

colorless to white

mp

128-131 °C (lit.)
128-131 °C

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤150 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

application(s)

cell analysis

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Gene Information

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This Item
N337672345481907
Nicotinamide ≥99.5% (HPLC)

72340

Nicotinamide

Nicotinamide ≥98% (HPLC), powder

N3376

Nicotinamide

Nicotinamide ≥98.5% (HPLC)

72345

Nicotinamide

Nicotinamide Precursor of the coenzymes NAD+ and NADP+.

481907

Nicotinamide

assay

≥99.5% (HPLC)

assay

≥98% (HPLC)

assay

≥98.5% (HPLC)

assay

≥99% (HPLC)

application(s)

cell analysis

application(s)

cell analysis

application(s)

-

application(s)

-

form

powder or crystals

form

powder

form

powder

form

solid

color

colorless to white

color

white

color

colorless to white

color

white

mp

128-131 °C (lit.)

mp

128-131 °C (lit.)

mp

128-131 °C (lit.)

mp

-

General description

Nicotinamide, a form of vitamin B3, is a building block of coenzymes NAD and NADP. Researchers consider it an important signaling molecule, and essential for cell metabolism studies. It has been used in multiple applications and research areas, namely cancer and viral research.

Application

Nicotinamide has been used:
  • to study its effect on the expression of sirtuin 1
  • in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay
  • in cell lysis buffer, to serve as a sirtuin 1 inhibitor in order to study its role in resveratrol (RSV)-stimulated hepatitis B virus replication

Biochem/physiol Actions

Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.
Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
The coenzymes NAD and NADP take part in energy yielding metabolism and mediate several oxidation-reduction reactions. NAD hydrolyses to form nicotinamide, which is then transported to other tissues. Hydrolysis of nicotinamide yields nicotinic acid through salvage pathway.

Other Notes

Coenzymes and Cofactors, vol. 2: Pyridine Nucleotide Coenzymes

related product

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Description
Pricing

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

302.0 °F - closed cup

flash_point_c

150 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Niacinamide United States Pharmacopeia (USP) Reference Standard

USP

1462006

Niacinamide

Nicotinamide Precursor of the coenzymes NAD+ and NADP+.

Millipore

481907

Nicotinamide

Niacinamide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1033

Niacinamide

Nicotinic acid ≥98%

Sigma-Aldrich

N4126

Nicotinic acid

Chemical, Biochemical and Medical Aspects, 776-776 null
D.Dolphin, R.Poulson, O.Avramovic, eds.
Chemical, Biochemical and Medical Aspects, 759-759 (1987)
Human Nutrition, 206-206 (2010)
Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1
You Z, et al.
Oncology Letters, 15(6), 9195-9201 (2018)
Resveratrol enhances HBV replication through activating Sirt1-PGC-1alpha-PPARalpha pathway
Shi Y, et al.
Scientific Reports, 6, 24744-24744 (2016)

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