N4126

Nicotinic acid

≥98%

• Synonym(s): 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B₃
• Empirical Formula (Hill Notation): C₆H₅NO₂
• CAS Number: 59-67-6
• Molecular Weight: 123.11
• Beilstein/REAXYS Number: 109591
• EC Number: 200-441-0
• MDL number: MFCD00006391
• UNSPSC Code: 12352106
• PubChem Substance ID: 24897668
• NACRES: NA.25

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• assay: ≥98%
• form: powder
• color: white to off-white
• mp: 236-239 °C (lit.)
• SMILES string: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChI key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Description

General description

Nicotinic acid is also known as vitamin B₃ or Niacin. It is a water soluble vitamin. Niacin can be either synthesized within the body or can be obtained from dietary sources.

Application

Nicotinic acid has been used:

• as a component of the MS vitamins stock solution
• for the detection of siderophores in Escherichia coli bacterial culture
• as a component of the holidic medium for adult Drosophila .

Biochem/physiol Actions

Niacin is involved in the production of nicotinamide adenine dinucleotide (NAD⁺), which is used in the adenine triphosphate (ATP) production in mitochondrial oxidative phosphorylation. It also decreases hepatic production of very-low density lipoproteins (VLDL), and apolipoprotein B (apo-B). Niacin deficiency leads to pellagra.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 379.4 °F - closed cup
• flash_point_c: 193 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves