MilliporeSigma

NLRP3

NLR family, pyrin domain containing 3

Synonyms:
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1
Species:
UniProtKB ID:
Gene ID:
  • Human(114548) Summary: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
  • Mouse(216799) NLR family, pyrin domain containing 3
  • Rat(287362) NLR family, pyrin domain containing 3
  • Domestic Rabbit(100351623) NLR family, pyrin domain containing 3
  • naked mole-rat(101712523) NLR family, pyrin domain containing 3
  • domestic cat(101092579) NLR family, pyrin domain containing 3
  • domestic guinea pig(100726352) NLR family, pyrin domain containing 3
  • chicken(423021) NLR family, pyrin domain containing 3
  • sheep(101107699) NLR family, pyrin domain containing 3
  • dog(490576) NLR family, pyrin domain containing 3
  • cow(538639) NLR family, pyrin domain containing 3

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CIAS1, (N-terminal) antibody produced in mouse, clone 3B1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-NLRP3 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-CIAS1/cryopyrin (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, human, rat
Application
ELISA
flow cytometry

immunofluorescence

immunohistochemistry
Anti-NLRP3 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-NLRP3 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NLRP3,
Species
human