MilliporeSigma

PLAT

plasminogen activator, tissue

Synonyms:
T-PA, TPA
Species:
UniProtKB ID:
Gene ID:
  • Human(5327) Summary: This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(18791) plasminogen activator, tissue
  • Rat(25692) plasminogen activator, tissue
  • naked mole-rat(101713266) plasminogen activator, tissue
  • domestic guinea pig(100725281) plasminogen activator, tissue
  • cow(281407) plasminogen activator, tissue
  • sheep(101118332) plasminogen activator, tissue
  • chicken(426791) plasminogen activator, tissue
  • domestic cat(101100299) plasminogen activator, tissue
  • Horse(100050239) plasminogen activator, tissue
  • dog(482840) plasminogen activator, tissue
  • Zebrafish(100320028) plasminogen activator, tissue
  • Domestic Rabbit(100009556) plasminogen activator, tissue

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ELISA

Product Number
Description
Species
Human TPA ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PLAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-PLAT antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-tPA/PLAT antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043), liquid, clone GMA-043, Calbiochem®,
Species Reactivity
human
Application
ANTI-TPA (CENTER) antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Aminocaproic acid, European Pharmacopoeia (EP) Reference Standard,
Species
human
Aminocaproic acid, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Aminocaproic acid, United States Pharmacopeia (USP) Reference Standard,
Species
human
6-Aminohexanoic acid, ≥98.5% (NT),
Species
human
6-Aminocaproic acid, BioUltra, ≥99%,
Species
rat, human

Proteins

Product Number
Description
Species
Tissue plasminogen activator human, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Plat,
Species
mouse
MISSION® esiRNA, targeting human PLAT,
Species
human