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PLCE1

phospholipase C, epsilon 1

Synonyms:
NPHS3, PLCE, PPLC
Species:
UniProtKB ID:
Gene ID:
  • Human(51196) Summary: This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
  • Mouse(74055) phospholipase C, epsilon 1
  • Rat(114633) phospholipase C, epsilon 1
  • domestic guinea pig(100721203) phospholipase C, epsilon 1
  • naked mole-rat(101706315) phospholipase C, epsilon 1
  • sheep(101105703) phospholipase C, epsilon 1
  • Domestic Rabbit(100344504) phospholipase C, epsilon 1
  • dog(486808) phospholipase C, epsilon 1
  • domestic cat(101088695) phospholipase C, epsilon 1
  • Horse(100061676) phospholipase C, epsilon 1
  • cow(519037) phospholipase C, epsilon 1
  • Zebrafish(568288) phospholipase C, epsilon 1
  • chicken(428962) phospholipase C, epsilon 1

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PLCE1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PLCE1,
Species
human
MISSION® esiRNA, targeting mouse Plce1,
Species
mouse