MilliporeSigma

PPM1F

protein phosphatase, Mg2+/Mn2+ dependent, 1F

Synonyms:
CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2
Species:
UniProtKB ID:
Gene ID:
  • Human(9647) Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
  • Mouse(68606) protein phosphatase 1F (PP2C domain containing)
  • Rat(287931) protein phosphatase, Mg2+/Mn2+ dependent, 1F
  • domestic cat(101087876) protein phosphatase, Mg2+/Mn2+ dependent, 1F
  • domestic guinea pig(100715460) protein phosphatase, Mg2+/Mn2+ dependent, 1F
  • naked mole-rat(101699789) protein phosphatase, Mg2+/Mn2+ dependent, 1F
  • Horse(100057884) protein phosphatase, Mg2+/Mn2+ dependent, 1F
  • cow(618210) protein phosphatase, Mg2+/Mn2+ dependent, 1F
  • dog(486448) protein phosphatase, Mg2+/Mn2+ dependent, 1F
  • Zebrafish(553757) protein phosphatase 1F (PP2C domain containing)
  • chicken(416772) protein phosphatase, Mg2+/Mn2+ dependent, 1F
  • sheep(101114979) protein phosphatase, Mg2+/Mn2+ dependent, 1F

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PPM1F, (N-terminal) antibody produced in mouse, clone 1G10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)

western blot
Anti-PPM1F antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
Anti-PPM1F antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-PPM1F antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-PPM1F antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
CaMKPase, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ppm1f,
Species
mouse