MilliporeSigma

PTPRC

protein tyrosine phosphatase, receptor type, C

Synonyms:
B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Species:
UniProtKB ID:
Gene ID:
  • Human(5788) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
  • Mouse(19264) protein tyrosine phosphatase, receptor type, C
  • Rat(24699) protein tyrosine phosphatase, receptor type, C
  • Zebrafish(559154) protein tyrosine phosphatase, receptor type, C
  • chicken(386580) protein tyrosine phosphatase, receptor type, C
  • domestic cat(101097123) protein tyrosine phosphatase, receptor type, C
  • Horse(100061950) protein tyrosine phosphatase, receptor type, C
  • dog(490255) protein tyrosine phosphatase, receptor type, C
  • sheep(101102917) protein tyrosine phosphatase, receptor type, C
  • cow(407152) protein tyrosine phosphatase, receptor type, C
  • Domestic Rabbit(100358807) protein tyrosine phosphatase, receptor type, C
  • naked mole-rat(101710515) protein tyrosine phosphatase, receptor type, C
  • domestic guinea pig(100730564) protein tyrosine phosphatase, receptor type, C

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CD45.1 Antibody (mouse), clone A20, clone A20, 0.5 mg/mL, from mouse,
Species Reactivity
mouse
Application
flow cytometry
immunohistochemistry

immunoprecipitation (IP)
Anti-CD45 (Mouse), PE-Cy7, clone 30-F11 Antibody, clone 30-F11, from rat, PE-Cy7,
Species Reactivity
mouse
Application
flow cytometry
Anti-CD45.1 Antibody (mouse), PE, clone A20, clone A20, 0.2 mg/mL, from mouse,
Species Reactivity
mouse
Application
flow cytometry
immunohistochemistry

immunoprecipitation (IP)
Anti-CD45.1 Antibody (mouse), PE, clone A20, clone A20, 0.2 mg/mL, from mouse,
Species Reactivity
mouse
Application
flow cytometry
immunohistochemistry

immunoprecipitation (IP)
Anti-CD45.2 Antibody (mouse), APC, clone 104, clone 104, 0.2 mg/mL, from mouse,
Species Reactivity
mouse
Application
flow cytometry
immunocytochemistry

immunoprecipitation (IP)

Small Molecule - Inhibitor

Product Number
Description
Species
9,10-Phenanthrenequinone, 95%,
Species
human
9,10-Phenanthrenequinone, ≥99%,
Species
human

Proteins

Product Number
Description
Species
CD45 Active human, recombinant, expressed in baculovirus infected insect cells, ≥90% (SDS-PAGE),
Species
human
PTPRC (592-end), active, GST tagged from mouse, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
mouse
CD45 Protein, 10 µg, His6-tagged, recombinant, human CD45, amino acids 598-end, for use in Enzyme Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PTPRC,
Species
human
MISSION® esiRNA, targeting mouse Ptprc,
Species
mouse