MilliporeSigma

TGFBR1

transforming growth factor, beta receptor 1

Synonyms:
AAT5, ACVRLK4, ALK-5, ALK5, LDS1A, LDS2A, MSSE, SKR4, TGFR-1
Species:
UniProtKB ID:
Gene ID:
  • Human(7046) Summary: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Mouse(21812) transforming growth factor, beta receptor I
  • Rat(29591) transforming growth factor, beta receptor 1
  • chicken(374094) transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
  • dog(481628) transforming growth factor, beta receptor 1
  • sheep(554326) transforming growth factor, beta receptor 1
  • cow(282382) transforming growth factor, beta receptor 1
  • domestic cat(101094057) transforming growth factor, beta receptor 1
  • naked mole-rat(101718090) transforming growth factor, beta receptor 1
  • domestic guinea pig(100715237) transforming growth factor, beta receptor 1

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-TGF β Receptor I antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Anti-TGF β receptor 1 Antibody, clone 4H18 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
ELISA
affinity binding assay

immunocytochemistry

western blot
Anti-TGFBR1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-TGFBR1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, rat
Application
ELISA
flow cytometry

immunohistochemistry

western blot
ANTI-TGF BETA RECEPTOR I (CENTER) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
LY-364947, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
TGFβR1 (80-end), GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
TGFβR1 (80-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
TGFBR-1 Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose. For use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Tgfbr1,
Species
mouse
MISSION® esiRNA, targeting human TGFBR1,
Species
human