TPH2
tryptophan hydroxylase 2
Synonyms:
ADHD7, NTPH
Species:
Human TPH2 (121278), Mouse Tph2 (216343), Rat Tph2 (317675), domestic guinea pig Tph2 (100724594), Horse TPH2 (100009684), sheep TPH2 (101120314), dog TPH2 (481165), domestic cat TPH2 (101082165), Domestic Rabbit TPH2 (100009100), Zebrafish tph2 (407712) ...More
UniProtKB ID:
Gene ID:
- Human(121278) Summary: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]
- Mouse(216343) tryptophan hydroxylase 2
- Rat(317675) tryptophan hydroxylase 2
- domestic guinea pig(100724594) tryptophan hydroxylase 2
- Horse(100009684) tryptophan hydroxylase 2
- sheep(101120314) tryptophan hydroxylase 2
- dog(481165) tryptophan hydroxylase 2
- domestic cat(101082165) tryptophan hydroxylase 2
- Domestic Rabbit(100009100) tryptophan hydroxylase 2
- Zebrafish(407712) tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
- chicken(408026) tryptophan hydroxylase 2
- naked mole-rat(101714361) tryptophan hydroxylase 2
- cow(100336620) tryptophan hydroxylase 2
- cow(618062) tryptophan hydroxylase 2
Small Molecule - Inhibitor
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