MilliporeSigma

TPM1

tropomyosin 1 (alpha)

Synonyms:
C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA
Species:
UniProtKB ID:
Gene ID:
  • Human(7168) Summary: This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
  • Mouse(22003) tropomyosin 1, alpha
  • Rat(24851) tropomyosin 1, alpha
  • chicken(396366) tropomyosin 1 (alpha)
  • Zebrafish(393908) tropomyosin 1 (alpha)
  • domestic cat(101091450) tropomyosin 1 (alpha)
  • dog(478332) tropomyosin 1 (alpha)
  • naked mole-rat(101714552) tropomyosin 1 (alpha)
  • sheep(100145865) tropomyosin 1 (alpha)
  • domestic guinea pig(100717160) tropomyosin 1 (alpha)
  • cow(281544) tropomyosin 1 (alpha)

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-TPM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-TPM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-Tropomyosin 1 Antibody, clone 5Q2H6, Rabbit Monoclonal, ,
Species Reactivity
mouse, rat
Application
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Tropomyosin Antibody, clone 15D12.2, clone 15D12.2, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-Tropomyosin-1 Antibody, clone 7F8B8, clone 7F8B8, from rat,
Species Reactivity
human, mouse
Application
immunocytochemistry
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Tpm1,
Species
mouse
MISSION® esiRNA, targeting human TPM1,
Species
human