MilliporeSigma

VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

Synonyms:
NR1I1
Species:
UniProtKB ID:
Gene ID:
  • Human(7421) Summary: This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
  • Mouse(22337) vitamin D receptor
  • Rat(24873) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • naked mole-rat(101710294) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • domestic guinea pig(100734655) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • sheep(101107273) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • sheep(100294603) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • cow(533656) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • Horse(100034072) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • domestic cat(100316614) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • dog(486588) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • chicken(395988) vitamin D (1,25- dihydroxyvitamin D3) receptor

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
Doxercalciferol, United States Pharmacopeia (USP) Reference Standard,
Species
human
Calcifediol, United States Pharmacopeia (USP) Reference Standard,
Species
human
Alfacalcidol for system suitability A, European Pharmacopoeia (EP) Reference Standard,
Species
human
Calcifediol for impurity D identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Ergocalciferol, British Pharmacopoeia (BP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
1α,25-Dihydroxyvitamin D3, ≥99% (HPLC),
Species
human
1α,25-Dihydroxyvitamin D3, ≥97.0% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Vitamin D3 Receptor Antibody, clone 6F3.1, clone 6F3.1, from mouse,
Species Reactivity
human
Application
western blot
Anti-Vitamin D Receptor antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-VDR antibody produced in mouse, clone 2F4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
Anti-phospho-Vitamin D Receptor (pSer208) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Anti-VDR antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human VDR,
Species
human