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1131009

USP

Cholecalciferol

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
(+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol
Empirical Formula (Hill Notation):
C27H44O
CAS Number:
Molecular Weight:
384.64
Beilstein/REAXYS Number:
2339331
MDL number:
PubChem Substance ID:

grade

pharmaceutical primary standard

API family

cholecalciferol

manufacturer/tradename

USP

mp

83-86 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

InChI key

QYSXJUFSXHHAJI-YRZJJWOYSA-N

Gene Information

human ... VDR(7421)

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This Item
C2100000C1357C9774
Cholecalciferol United States Pharmacopeia (USP) Reference Standard

1131009

Cholecalciferol

Cholecalciferol European Pharmacopoeia (EP) Reference Standard

C2100000

Cholecalciferol

Cholecalciferol meets USP testing specifications

C1357

Cholecalciferol

Cholecalciferol analytical standard

C9774

Cholecalciferol

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

-

format

neat

format

neat

format

-

format

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

API family

cholecalciferol

API family

cholecalciferol

API family

-

API family

-

mp

83-86 °C (lit.)

mp

83-86 °C (lit.)

mp

83-86 °C (lit.)

mp

83-86 °C (lit.)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cholecalciferol USP reference standard for use in specified quality tests and assays.

Also used to prepare standard and standard stock solutions for the assay, identification and performance tests according to the given below monographs of United States Pharmacopeia (USP):
  • Cholecalciferol
  • Cholecalciferol Tablets
  • Cholecalciferol Solution

Biochem/physiol Actions

Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Sigma-Aldrich

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Cholecalciferol
United States Pharmacopeia, 44(6), 985-985 (2020)
Cholecalciferol Solution
United States Pharmacopeia, 987-987 (2013)
Cholecalciferol Tablets
United States Pharmacopeia, 43(2), 988-988 (2018)
Robert Scragg et al.
Hypertension (Dallas, Tex. : 1979), 64(4), 725-730 (2014-07-02)
Previous randomized controlled trials of vitamin D supplementation and blood pressure (BP) mainly have given vitamin D for short periods (<6 months) or at low doses (400 IU per day). This study aims to determine whether long-term high-dose vitamin D
Sagar U Nigwekar et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 60(1), 139-156 (2012-05-09)
The development of chronic kidney disease (CKD) is accompanied by a progressive decrease in the ability to produce 1,25-dihydroxyvitamin D. Pharmacological replacement with active vitamin D therefore has been a cornerstone of secondary hyperparathyroidism therapy in the end-stage renal disease

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