MilliporeSigma

VKORC1

vitamin K epoxide reductase complex, subunit 1

Synonyms:
EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
Species:
UniProtKB ID:
Gene ID:
  • Human(79001) Summary: Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(27973) vitamin K epoxide reductase complex, subunit 1
  • Rat(309004) vitamin K epoxide reductase complex, subunit 1
  • cow(445422) vitamin K epoxide reductase complex, subunit 1
  • domestic guinea pig(100717597) vitamin K epoxide reductase complex, subunit 1
  • naked mole-rat(101712530) vitamin K epoxide reductase complex, subunit 1
  • dog(479775) vitamin K epoxide reductase complex, subunit 1
  • Zebrafish(100000559) vitamin K epoxide reductase complex, subunit 1
  • chicken(404205) vitamin K epoxide reductase complex, subunit 1
  • domestic cat(101089669) vitamin K epoxide reductase complex, subunit 1

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Small Molecule - Inhibitor

Product Number
Description
Species
3-(α-Acetonylbenzyl)-4-hydroxycoumarin sodium salt, ≥98%,
Species
human
Warfarin, United States Pharmacopeia (USP) Reference Standard,
Species
human
Warfarin, analytical standard,
Species
human
Warfarin, PESTANAL®, analytical standard,
Species
human
Warfarin sodium, European Pharmacopoeia (EP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human VKORC1,
Species
human
MISSION® esiRNA, targeting mouse Vkorc1,
Species
mouse