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A5111

Sigma-Aldrich

ABT-724 trihydrochloride

≥98% (HPLC)

Synonym(s):

2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride

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10 G
$40.40
50 G
$138.00
250 G
$527.25

About This Item

Empirical Formula (Hill Notation):
C17H19N5 · 3HCl
CAS Number:
Molecular Weight:
402.75
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

$40.40


Available to ship onApril 11, 2025Details


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assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: >30 mg/mL

originator

Abbott

storage temp.

2-8°C

SMILES string

Cl.Cl.Cl.C1CN(CCN1Cc2nc3ccccc3[nH]2)c4ccccn4

InChI

1S/C17H19N5.3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17;;;/h1-8H,9-13H2,(H,19,20);3*1H

InChI key

AZFUVPBLKQGSRI-UHFFFAOYSA-N

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This Item
56754045024374875
assay

≥90% (titration)

assay

-

assay

99.98% trace metals basis

assay

≥90% (HPCE)

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

solubility

H2O: soluble

solubility

water: 10 mg/mL

solubility

-

solubility

DMF: soluble, DMSO: soluble, H2O: soluble, methanol: soluble

color

white to off-white

color

white to off-white

color

-

color

-

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Application

ABT-724 is a dopamine D4 receptor agonist. ABT-724 has been used in the study of impulsive behavior and penile erection in rats.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Roy M Daniel et al.
The Biochemical journal, 425(2), 353-360 (2009-10-24)
Experimental data show that the effect of temperature on enzymes cannot be adequately explained in terms of a two-state model based on increases in activity and denaturation. The Equilibrium Model provides a quantitative explanation of enzyme thermal behaviour under reaction
Laszlo Tretter et al.
Journal of neurochemistry, 83(4), 855-862 (2002-11-08)
Previously we have reported that oxidative stress induced by hydrogen peroxide exacerbates the effect of an Na+ load in isolated nerve terminals, with a consequence of an ATP depletion, [Ca2+]i and [Na+]i deregulation, and collapse of mitochondrial membrane potential. In
Decreased carbohydrate metabolism enzyme activities in the glaucomatous trabecular meshwork
Junk AK, Goel M, Mundorf T, Rockwood EJ, Bhattacharya SK
Molecular Vision, 10, 1286-1291 (2010)
S M Kuo et al.
Biology of the neonate, 43(1-2), 23-32 (1983-01-01)
The tissue distribution, the subcellular distribution in liver, and the developmental patterns of cysteine:alpha-ketoglutarate aminotransferase (CAT) and 3-mercaptopyruvate sulfurtransferase (MPST) activities were determined in rats of the Sprague-Dawley strain. CAT activity was highest in heart and liver, whereas MPST activity
Vasily A Aleshin et al.
International journal of molecular sciences, 23(19) (2022-10-15)
Glutamate dehydrogenase (GDH) plays a key role in the metabolism of glutamate, an important compound at a cross-road of carbon and nitrogen metabolism and a relevant neurotransmitter. Despite being one of the first discovered allosteric enzymes, GDH still poses challenges

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