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B161

Sigma-Aldrich

B-HT 933 dihydrochloride

≥98% (HPLC), solid

Synonym(s):

6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride, Azepexole dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H15N3O · 2HCl
CAS Number:
36067-72-8
Molecular Weight:
254.16
MDL number:
MFCD01529923
UNSPSC Code:
12352200
PubChem Substance ID:
24277762

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

H2O: >20 mg/mL

SMILES string

Cl.Cl.CCN1CCc2nc(N)oc2CC1

InChI

1S/C9H15N3O.2ClH/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7;;/h2-6H2,1H3,(H2,10,11);2*1H

InChI key

HBLPYIOKPJVFQW-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Biochem/physiol Actions

Selective α2-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
037K47132
037K47131
037K4713
017K4718
061K4705

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S Sarkar et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 281(6), R1966-R1974 (2001-11-14)
The placenta expresses high levels of 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) that converts cortisol into inactive 11-keto metabolites and effectively protects the developing fetus from maternal cortisol during pregnancy. Impairment of this glucocorticoid barrier has adverse effects on fetal outcomes.
David M Keller et al.
The Journal of physiology, 588(Pt 19), 3799-3808 (2010-08-10)
This study tested the hypothesis that passive leg heating attenuates α-adrenergic vasoconstriction within that limb. Femoral blood flow (FBF, femoral artery ultrasound Doppler) and femoral vascular conductance (FVC, FBF/mean arterial blood pressure), as well as calf muscle blood flow (CalfBF
Luis E Cobos-Puc et al.
European journal of pharmacology, 616(1-3), 175-182 (2009-06-17)
This study analysed the inhibition produced by the agonists moxonidine (imidazoline I(1) receptors>alpha(2)-adrenoceptors) and agmatine (endogenous ligand of imidazoline I(1)/I(2) receptors), using B-HT 933 (6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride; alpha(2)-adrenoceptors) for comparison, on the rat cardioaccelerator sympathetic outflow. Male Wistar rats were pithed
S E Browne et al.
Brain research, 666(2), 216-222 (1994-12-15)
The anti-hypertensive drug, rilmenidine, has activity at both imidazoline-preferring receptors (IPRs) and alpha 2-adrenoceptors. However, available evidence suggests that its hypotensive effect is mediated via central IPRs. In the present study, the neuroanatomical regions involved in mediating the hypotensive response
Ma Trinidad Villamil-Hernández et al.
European journal of pharmacology, 691(1-3), 118-124 (2012-06-21)
It has been shown that α(2)-adrenoceptors mediate vasopressor responses in pithed rats. However, the corresponding α(2)-adrenoceptor subtypes have not been pharmacologically identified. Thus, this study set out to identify the specific subtypes (α(2A), α(2B) and α(2C)) mediating the vasopressor responses
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