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Key Documents

D9667

Sigma-Aldrich

α-Dendrotoxin

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About This Item

CAS Number:
74504-53-3
MDL number:
MFCD00162007
UNSPSC Code:
12352200

storage temp.

−20°C

Amino Acid Sequence

Gln-Pro-Arg-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Asp-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Arg-Phe-Asp-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Gly

Biochem/physiol Actions

Blocks slowly inactivating outward K+ current; blocks voltage-gated K+-channels in rat brain synaptosomes; increases acetylcholine release at neuromuscular junction.

Other Notes

Isolated initially from Dendroaspis angusticeps (eastern green mamba)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
SLBH1321V
SLBF4729V
SLBF0721V
120M1299
120M1300

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  5. What is the molecular weight of Product D9667, α-Dendrotoxin?

    Product D9667, α-Dendrotoxin contains 59 residues with a formula weight of 7077 daltons.

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F J Joubert et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 361(5), 661-674 (1980-05-01)
Toxins C13S1C3 and C13S2C3 from D. angusticeps venom were purified by gel filtration and ion exchange chromatography. Whereas C13S1C3 contains 57 amino acids, C13S2C3 contains 59 but each include six half-cystine residues. The complete primary structure of the low toxicity
K Schmidt et al.
Brain research, 843(1-2), 145-160 (1999-10-21)
Outwardly rectifying K(+) channels determine the membrane conductance and influence the proliferation rate of glial progenitor cells. To analyze the molecular identity and the functional role of K(+) channels in glial progenitors of mouse brain, expression of shaker-type Kv1 genes
S Gasparini et al.
The Journal of biological chemistry, 273(39), 25393-25403 (1998-09-17)
We identified the residues that are important for the binding of alpha-dendrotoxin (alphaDTX) to Kv1 potassium channels on rat brain synaptosomal membranes, using a mutational approach based on site-directed mutagenesis and chemical synthesis. Twenty-six of its 59 residues were individually
Y P Tan et al.
The Journal of physiology, 520 Pt 1, 65-78 (1999-10-12)
1. Action potential-evoked [Ca2+]i rises in basket cell axons of rat cerebellar slices were studied using two-photon laser scanning microscopy and whole-cell recording, to identify the K+ channels controlling the shape of the axonal action potential. 2. Whole-cell recordings of
Seiichiro Jinde et al.
The European journal of neuroscience, 30(6), 1036-1055 (2009-09-09)
Gamma oscillations are a prominent feature of hippocampal network activity, but their functional role remains debated, ranging from mere epiphenomena to being crucial for information processing. Similarly, persistent gamma oscillations sometimes appear prior to epileptic discharges in patients with mesial

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