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T154

Sigma-Aldrich

Tityustoxin-Kα from Tityus serrulatus (Brazilian scorpion) venom

lyophilized powder

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About This Item

CAS Number:
39465-37-7
MDL number:
MFCD00212758
UNSPSC Code:
12352200

form

lyophilized powder

solubility

H2O: soluble

storage temp.

−20°C

Gene Information

human ... KCNS1(3787) , KCNS2(3788)
mouse ... KCNS1(16538) , KCNS2(16539)
rat ... KCNS1(117023) , KCNS2(66022)

Amino Acid Sequence

Val-Phe-Ile-Asn-Ala-Lys-Cys-Arg-Gly-Ser-Pro-Glu-Cys-Leu-Pro-Lys-Cys-Lys-Glu-Ala-Ile-Gly-Lys-Ala-Ala-Gly-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro

Biochem/physiol Actions

Potent and selective voltage-gated non-inactivating (delayed-rectifier) K+ channel blocker.

Caution

Hygroscopic, photosensitive. Only plastic tubes should be used with this product.

Legal Information

Sold under license from the University of Maryland.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Ana Leonor A Nencioni et al.
Toxicon : official journal of the International Society on Toxinology, 44(2), 179-183 (2004-07-13)
We examined the effects of dantrolene, an inhibitor of intracellular calcium release, on alterations associated with the intrahippocampal injection of the TsTX scorpion toxin. Male Wistar rats (230-250 g) were injected with Ringer solution (1 microl; n = 6); TsTX
Aldo Rogelis A Rodrigues et al.
British journal of pharmacology, 139(6), 1180-1186 (2003-07-23)
1. We investigated the action of TsTX-Kalpha on cloned Kv1.3 channels of the Shaker subfamily of voltage-gated potassium channels, using the voltage-clamp technique. Highly purified TsTX-Kalpha was obtained from the venom of the Brazilian scorpion Tityus serrulatus using a new
T R Werkman et al.
Molecular pharmacology, 44(2), 430-436 (1993-08-01)
The interaction between two nonhomologous K+ channel toxins, Tityus serrulatus (scorpion) toxin tityustoxin-K alpha (TsTX-K alpha) and Dendroaspis angusticeps (snake) toxin dendrotoxin (alpha-DTX), was investigated on K+ currents in B82 fibroblast cells transformed to express the Kv1.2 K+ channel. As
R S Rogowski et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(4), 1475-1479 (1994-02-15)
Two nonhomologous polypeptide toxins, tityustoxin K alpha (TsTX-K alpha) and tityustoxin K beta (TsTX-K beta), purified from the venom of the Brazilian scorpion Tityus serrulatus, selectively block voltage-gated noninactivating K+ channels in synaptosomes (IC50 values of 8 nM and 30
Patrícia Alves Maia Guidine et al.
Neurotoxicology, 29(1), 136-142 (2007-11-23)
The scorpion envenoming syndrome is a serious public health matter in Brazil. Previous results from our laboratory suggest that the effects of scorpion toxins on the central nervous system play a major role on the lethality induced by scorpion envenoming.
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