- A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.
A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.
Proceedings of the National Academy of Sciences of the United States of America (1980-11-01)
L M Hjelmeland
PMID6935651
ABSTRACT
The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be effective at solubilizing membrane proteins in a nondenatured state.