Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action.

Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action.

Chemical communications (Cambridge, England) (2010-12-15)

Hui Ming Ge, Wei Yan, Zhi Kai Guo, Qiong Luo, Rui Feng, Le Yun Zang, Yan Shen, Rui Hua Jiao, Qiang Xu, Ren Xiang Tan

ABSTRACT

Precursor-fed cultivation of endophytic Chaetomium globosum 1C51 afforded nine novel "unnatural" halogenated chaetoglobosins including those with more preferable immunosuppressive activity.

MATERIALS

Product Number

Brand

Product Description

SML0642

Sigma-Aldrich

Chaetoglobosin A, from Chaetomium globosum, ≥98% (HPLC)

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