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  • Acetoacetanilides as masked isocyanates: facile and efficient synthesis of unsymmetrically substituted ureas.

Acetoacetanilides as masked isocyanates: facile and efficient synthesis of unsymmetrically substituted ureas.

Organic letters (2010-09-03)
Ying Wei, Jing Liu, Shaoxia Lin, Hongqian Ding, Fushun Liang, Baozhong Zhao
ABSTRACT

A general and practical method for the preparation of unsymmetrically substituted ureas has been developed. By the reactions of acetoacetanilides with various amines including primary/secondary amines, a series of substituted aryl ureas were achieved in high yields. Acetoacetanilide substrates can be considered as masked reagents that liberate reactive isocyanates in situ.

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Sigma-Aldrich
2-Methylpiperidine, 98%
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25 g
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100 g
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Sigma-Aldrich
Acetoacetanilide, ≥99.5%
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SKUPack SizeAvailabilityPriceQuantity
25 g
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$40.20
100 g
In Stock
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$81.20