Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.

Bioorganic & medicinal chemistry letters (2006-04-20)

William J Watkins, James M Chen, Aesop Cho, Lee Chong, Nicole Collins, Maria Fardis, Wei Huang, Magdeleine Hung, Thorsten Kirschberg, William A Lee, Xiaohong Liu, William Thomas, Jie Xu, Ameneh Zeynalzadegan, Jennifer Zhang

PMID16621550

ABSTRACT

The design, synthesis, and IMPDH inhibitory activity of a series of phosphonic acid-containing analogues of mycophenolic acid are described.

MATERIALS

Product Number

Brand

Product Description

M3536

Sigma-Aldrich

Mycophenolic acid, powder, BioReagent, suitable for cell culture

M5255

Sigma-Aldrich

Mycophenolic acid, ≥98%