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Microbial metabolism and biotechnological production of D-allose.

Applied microbiology and biotechnology (2011-06-10)
Yu-Ri Lim, Deok-Kun Oh
ABSTRACT

D-allose has attracted a great deal of attention in recent years due to its many pharmaceutical activities, which include anti-cancer, anti-tumor, anti-inflammatory, anti-oxidative, anti-hypertensive, cryoprotective, and immunosuppressant activities. D-allose has been produced from D-psicose using D-allose-producing enzymes, including L-rhamnose isomerase, ribose-5-phosphate isomerase, and galactose-6-phosphate isomerase. In this article, the properties, applications, and metabolism of D-allose are described, and the biochemical properties of D-allose-producing enzymes and their D-allose production are reviewed and compared. Moreover, several methods for effective D-allose production are suggested herein.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
D-Psicose, ≥95% (HPLC)
Sigma-Aldrich
Phosphoriboisomerase from spinach, Type I, partially purified powder, ≥40 units/mg protein (biuret)
Sigma-Aldrich
D-Allose, 98%
Sigma-Aldrich
β-D-Allose, rare aldohexose sugar