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  • Larch arabinogalactan for dry eye protection and treatment of corneal lesions: investigations in rabbits.

Larch arabinogalactan for dry eye protection and treatment of corneal lesions: investigations in rabbits.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (2007-11-16)
Susi Burgalassi, Nadia Nicosia, Daniela Monti, Giulia Falcone, Enrico Boldrini, Patrizia Chetoni
ABSTRACT

The aim of the present study was to investigate the corneal protective and healing properties of arabinogalactan (AG), a natural polysaccharide present in conifers of the genus Larix (Larch). AG was tested in comparison with other two polysaccharides possessing well-established properties in the treatment of dry eye: tamarind seed polysaccharide and hyaluronic acid. The AG formulation was subjected to the following investigations: rheologic measurements; evaluation of mucoadhesive properties by rheologic interaction with mucin; ferning test; and in vivo evaluation on rabbits, including treatment of an experimental dry eye; evaluation of the preocular retention; and evaluation of healing rate of experimental corneal wound. AG dispersions showed a newtonian nonviscous behavior, eta = 1.6 mPa . s for 10% w/w solution; it possessed good mucoadhesive properties useful for retention on the eye surface. In fact, a prolonged time of residence in rabbit eyes was ascertained using fluorescein-labeled AG. Five percent (5.0%) w/w AG exerted a good protective effect against the appearance of corneal dry spots. It also reduced significantly the healing time of an experimental corneal lesion since 27 h after the first treatment. These findings suggest that AG may be a potential therapeutic product for dry eye protection and for the treatment of corneal wounds.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(+)-Arabinogalactan, ≥80% (HPLC), from larch wood